PG Calculator 1.5a serial key or number
PG Calculator 1.5a serial key or number
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Biological Activity
Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays > fold selectivity over ALK3 and ALK6 and > fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = nM).
Technical Data
| M. Wt | |
| Formula | C22H16N4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | |
| PubChem ID | |
| InChi Key | FVRYPYDPKSZGNS-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM |
|---|---|---|
| Solubility | ||
| DMSO | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| mM | mL | mL | mL |
| 1 mM | mL | mL | mL |
| 2 mM | mL | mL | mL |
| 10 mM | mL | mL | mL |
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Dilution Calculator
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Reconstitution Calculator
References
References are publications that support the biological activity of the product.
Citations (1)
Citations are publications that use Bio-techne products. Selected citations for ML include:
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Certificate of Analysis
To download a Certificate of Analysis, please select a batch below.
Pythagorean Right-Angled Triangles
| Triple | primitive? | m,n |
|---|---|---|
| 3, 4, 5 | primitive | 2,1 |
| 5, 12, 13 | primitive | 3,2 |
| 6, 8, 10 | 2× 3, 4, 5 | 3,1 |
| 7, 24, 25 | primitive | 4,3 |
| 8, 15, 17 | primitive | 4,1 |
| 9, 12, 15 | 3× 3, 4, 5 | – |
| 9, 40, 41 | primitive | 5,4 |
| 10, 24, 26 | 2× 5, 12, 13 | 5,1 |
| 11, 60, 61 | primitive | 6,5 |
| 12, 16, 20 | 4× 3, 4, 5 | 4,2 |
| 12, 35, 37 | primitive | 6,1 |
| 13, 84, 85 | primitive | 7,6 |
| 14, 48, 50 | 2× 7, 24, 25 | 7,1 |
| 15, 20, 25 | 5× 3, 4, 5 | – |
| 15, 36, 39 | 3× 5, 12, 13 | – |
| 15, , | primitive | 8,7 |
| 16, 30, 34 | 2× 8, 15, 17 | 5,3 |
| 16, 63, 65 | primitive | 8,1 |
| 17, , | primitive | 9,8 |
| 18, 24, 30 | 6× 3, 4, 5 | – |
| 18, 80, 82 | 2× 9, 40, 41 | 9,1 |
| 19, , | primitive | 10,9 |
| 20, 48, 52 | 4× 5, 12, 13 | 6,4 |
| 20, 99, | primitive | 10,1 |
| 20, 21, 29 | primitive | 5,2 |
| Triple | primitive? | m,n |
|---|---|---|
| 21, 28, 35 | 7× 3, 4, 5 | – |
| 21, 72, 75 | 3× 7, 24, 25 | – |
| 21, , | primitive | 11,10 |
| 22, , | 2× 11, 60, 61 | 11,1 |
| 23, , | primitive | 12,11 |
| 24, 32, 40 | 8× 3, 4, 5 | 6,2 |
| 24, 45, 51 | 3× 8, 15, 17 | – |
| 24, 70, 74 | 2× 12, 35, 37 | 7,5 |
| 24, , | primitive | 12,1 |
| 25, 60, 65 | 5× 5, 12, 13 | – |
| 25, , | primitive | 13,12 |
| 26, , | 2× 13, 84, 85 | 13,1 |
| 27, 36, 45 | 9× 3, 4, 5 | 6,3 |
| 27, , | 3× 9, 40, 41 | – |
| 27, , | primitive | 14,13 |
| 28, 96, | 4× 7, 24, 25 | 8,6 |
| 28, 45, 53 | primitive | 7,2 |
| 28, , | primitive | 14,1 |
| 29, , | primitive | 15,14 |
| 30, 40, 50 | 10× 3, 4, 5 | – |
| 30, 72, 78 | 6× 5, 12, 13 | – |
| 30, , | 2× 15, , | 15,1 |
| 31, , | primitive | 16,15 |
| 32, 60, 68 | 4× 8, 15, 17 | 8,2 |
| 32, , | 2× 16, 63, 65 | 9,7 |
| 32, , | primitive | 16,1 |
| Triple | primitive? | m,n |
|---|---|---|
| 33, 44, 55 | 11× 3, 4, 5 | – |
| 33, , | 3× 11, 60, 61 | – |
| 33, , | primitive | 17,16 |
| 33, 56, 65 | primitive | 7,4 |
| 34, , | 2× 17, , | 17,1 |
| 35, 84, 91 | 7× 5, 12, 13 | – |
| 35, , | 5× 7, 24, 25 | – |
| 35, , | primitive | 18,17 |
| 36, 48, 60 | 12× 3, 4, 5 | – |
| 36, , | 4× 9, 40, 41 | 10,8 |
| 36, , | 3× 12, 35, 37 | – |
| 36, , | primitive | 18,1 |
| 36, 77, 85 | primitive | 9,2 |
| 37, , | primitive | 19,18 |
| 38, , | 2× 19, , | 19,1 |
| 39, 52, 65 | 13× 3, 4, 5 | – |
| 39, , | 3× 13, 84, 85 | – |
| 39, , | primitive | 20,19 |
| 39, 80, 89 | primitive | 8,5 |
| 40, 96, | 8× 5, 12, 13 | 10,2 |
| 40, 75, 85 | 5× 8, 15, 17 | – |
| 40, , | 2× 20, 99, | 11,9 |
| 40, , | primitive | 20,1 |
| 40, 42, 58 | 2× 20, 21, 29 | 7,3 |
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